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The Human Centipede (First Sequence) is a 2010 Dutch horror film written and directed by Tom Six. It stars Dieter Laser, Ashley C. Williams, Ashlynn Yennie, and Akihiro Kitamura. The film tell the story of a German doctor who kidnap three tourists and joins them surgically, mouth to anus, forming a "human centipede".[2] Having completed the operation, the doctor begin preparation the centipede, while attempting to hide his actions from the notice of the outside world.

The concept of the film arose from a joke Tom Six made with friends about punishing child molesters by stitching their mouth to the anus of a fat truck driver.[3] When forthcoming investors prior to filming, Six did not talk about the mouth-to-anus aspect of the plot, fearing it would put off potential backers. The financiers of The Human Centipede did not find out the full nature of the film until it was complete.[3]

The Human Centipede received mixed reviews but several accolade at various international film festivals. The film was released in the United States on Video on Demand on April 28, 2010, and in partial release theatrically on April 30. Tom Six begin working on a sequel, The Human Centipede (Full Sequence) which will be released in 2011